Seraj, Mohammad; Murugan, N Arul (Advisor); Subramanyam, A V (Advisor)(IIIT-Delhi, 2024-05-01)
In the ever-evolving landscape of medical innovation, the pursuit of accurate and efficient diagnostic tools for neurodegenerative diseases, notably Alzheimer's, has become increasingly urgent. The relentless progression ...
Tejas; Murugan, N Arul (Advisor)(IIIT-Delhi, 2023-08)
Drug discovery is divided into 4 phases. The first phase is in-silico processes beginning with target identification and validation, followed by the hit discovery process, assay development, high throughput screening, ...
Gupta, Srijanee; Raghava, Gajendra Pal Singh (Advisor)(IIIT-Delhi, 2023-07)
ThpPred is a web-based tool, developed for predicting druggable proteins/peptides. The main dataset used in this study contained 356 therapeutic proteins/peptides and 356 random proteins/peptides, curated from DrugBank, ...
Cardiovascular disease (CVD) remains a significant global health challenge, influenced by a complex interplay of genetic and environmental factors. Dysregulated lipid metabolism, a key contributor to CVD, disrupts cholesterol ...
Epigenetic memory is a vital cellular process. It regulates the inheritance of certain efficient traits of normal cells and the traits attained lately by the cells affected by diseases like Cancer from parents to daughter ...
The intricate nature of tumor heterogeneity and the personalized responses of cancer patients to drug treatments present significant challenges in the field of oncology. In this thesis, I aim to address such challenges by ...
The cellular mechanisms in yeast are highly conserved with humans making it an inexpensive, rapid and easier model organism to work with. Cell cycle checkpoints, DNA repair pathways and CDKs are well studied in yeast and ...
Detection of cancer for diagnosis and tracking the prognosis of the patients using liquid biopsy procedure: the extraction of blood for the detection of cells is the least invasive procedure and relatively fast process ...
The training and deployment of YOLOv4 and YOLOv5 models in an Android application play a vital role in achieving real-time object detection on mobile devices. This abstract overviews the critical steps in training and ...
Lipid homeostasis refers to the balance of the levels of various lipids, such as fats and cholesterol, within cells and organisms. This balance is crucial for many physiological functions. Disruptions to lipid homeostasis, ...
G L, Harika; K, Sriram (Advisor)(IIIT-Delhi, 2023-08)
One of the challenging tasks in systems-level modeling is determining the bistable dynamics from the networks constructed from the experiments. A necessary but not sufficient condition for bistability is the presence of ...
Kaur, Dashleen; Raghava, Gajendra Pal Singh (Advisor)(IIIT-Delhi, 2022-12)
Hormones play a crucial role in communicating information between cells and organs; responsible for regulating almost all the physiological processes of organisms. Thus, it is important to collect, compile and mine hormones ...
The cryo-electron microscopy (cryo-EM) technique captures 2D projections of biological structures, revealing their inherent Heterogeneity arising from structural flexibility, conformational changes, and distinct functional ...
Background: Studying Chromatin Architecture is paramount to an understanding of cells or nuclei in disease and normal state. With recent advances in genomic technologies and computational power, new domains like Topologically ...
An increase in research and development of single-cell genomics led to various insights into cells and their function, it has become a primary focus of research leading to many great discoveries. RNA velocity is one such ...
C, Aparna; Murugan, N Arul (Advisor)(IIIT-Delhi, 2023-05)
Drug discovery is a complex, time-consuming, and challenging process, but the introduction of computational methods, especially machine learning, and deep learning models, has accelerated the entire process. OnionNet is a ...
Across evolutionary history, every organism has developed the ability to adapt to fluctuations in environmental conditions, thereby striking a balance between efficient growth and survival. In the case of yeast, when exposed ...
Inflammatory Bowel Diseases (IBD), encompassing Crohn’s Disease (CD) and Intestinal Tuberculosis (ITB), present similar clinical symptoms but require distinct treatment strategies. This study investigates microbiome and ...
Srivastava, Aman; Raghava, Gajendra Pal Singh (Advisor)(IIIT-Delhi, 2023-02)
Alzheimer’s disease is progressing as the most prevalent neurological disorder world- wide. It is the most common cause of dementia in ageing society. An artificial Neural Network (ANN) is a set of neural networks which ...
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) is an aspartyl protease with a transmembrane domain that cleaves at the 671st position of amyloid precursor protein (APP) at the beta site. The production and ...