Aging is a progressive, multifactorial biological process that drives the risk of nearly all major chronic diseases, including cancer, neurodegeneration, metabolic disorders, frailty, and cardiovascular dysfunction. Although ...

Cholesteryl Ester Transfer Protein (CETP) exchanges cholesteryl esters (CEs) and triglycerides (TGs) between lipoproteins, modulating their composition. This process regulates plasma CE and TG content and therefore strongly ...

G-protein-coupled receptors (GPCRs) are vital pharmaceutical targets, with more than one-third of FDA-approved drugs influencing their function. While central to cellular signaling and drug development, GPCR research is ...

Understanding and predicting complex biological processes, from the interactions of molecules to the aging of cells, relies heavily on the ability to extract useful information from different types of biological data. ...

Cooking is a quintessential creative pursuit with profound significance for humanity. Food and cooking transcend mere sensory pleasure and have serious nutrition and public health outcomes. Beyond being linked to the ...

There are thousands of genes with incomplete functional annotations, particularly non-coding genes. Understanding the functional roles of genes is crucial for dissecting the complex genomic regulatory mechanisms underlying ...

Healthcare has been undergoing a data-driven transformation, further accelerated by the COVID-19 pandemic. A significant amount of healthcare data is unstructured and underutilized. The success of Large Language Models ...

Cancer has become the second leading cause of mortality worldwide, and early de-tection and adequate treatment are crucial in reducing the cancer burden. Metastasis,which involves malignant cells detaching from the primary ...

Omic signatures of disease are important for personalized treatment because of theheterogeneity of diseases. Despite the advancement of computational tools, there arelimited methods that can capture the latent inter-relationships ...

The advent of tissue and single cell based transcriptomic profiling technologies has allowed precise characterization of tissue specific gene activities in the context of development and disease. Human cells express about ...