Insight from RNA-DNA interaction for regulation of activity of repeat elements and genes

Abstract

The RNA world is yet to be understood properly, and the same goes for repeat regions as there has been much research going on to understand their regulatory roles. Here, we have analyzed the RNA-DNA interaction and their relationship with the regulation to better understand this unexplored data. We explored the possibility of relationships among different repeat families through the mechanism of RNA-DNA interaction. We also added the dimension of histone modifications to understand the effect of many non-coding RNA through binding to DNA. We explored the different pathways affected by the binding of a few non-coding RNA to DNA. Our analysis highlighted the bias in the DNA binding pattern of GAS5 known to be involved in various diseases, including diabetes mellitus, cancer, and bone disorders. Our analysis also highlighted transcription factors that could be involved in the binding of a few non-coding RNA to DNA. 3