Compilation and analysis of tumor-homing peptides

Abstract

TumorHoPe2 is a comprehensive bioinformatics resource focused on tumor homing peptides (THPs), designed to support cancer research and targeted therapy development. Leveraging the base of a previous platform created in 2012, this new system much more expansively and deeply offers data. The new version includes 1847 carefully curated records, which constitute 1297 distinct peptide sequences, effectively doubling the dataset of its successor. Each peptide entry is annotated with essential attributes such as amino acid sequence, terminal or chemical modifications, associated tumor types, and corresponding cancer cell lines. This information is sourced from two key experimental methodologies: phage display libraries and synthetic peptides. The dataset includes 594 chemically modified peptides, detailing 255 N-terminal modifications and 195 C-terminal modifications. These peptides have been studied across 172 distinct cancer cell lines, targeting 37 different tumor types. Advanced features like search, filtering, and visualization tools, as well as a RESTful API are offered by the database to ensure seamless accessibility and usefulness for researchers. The resource is freely accessible at: https://webs.iiitd.edu.in/raghava/tumorhope2