Deciphering the genetic bias underlying in global population for lipid homeostasis

Abstract

Maintaining lipid homeostasis, the equilibrium of lipid levels, including fats and cholesterol within cells and organisms, is vital for numerous physiological functions. Disruptions in lipid homeostasis, often spurred by missense mutations in lipid metabolism-associated protein, can result in conditions like hyperlipidemia, elevating the risk of heart disease and other health issues. Currently, extensive research is ongoing to unravel the genetic foundations of lipid homeostasis across diverse populations, aiming to inform personalized strategies for managing lipid levels, such as dietary interventions. To contribute to this research domain, study focused on identifying prevalent genetic variations linked to lipid balance regulation in different populations. The investigation delved into discerning mutational patterns and understanding the implications of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein structures.