A, Haseena; Kumar, Vibhor (Advisor)(IIIT-Delhi, 2025-06-18)
Regenerative medicine relies on the precise control of stem cell differentiation. While mesenchymal stem cells (MSCs) and human embryonic stem cells (hESCs) hold great promise, current differentiation methods struggle with ...
Bai O P, Kavya; Ghosh, Tarini Shankar (Advisor)(IIIT-Delhi, 2025-07-24)
Celiac disease (CeD) is a chronic immune-mediated enteropathy triggered by the ingestion of gluten, a storage protein complex found in wheat, rye, and barley. Gluten comprises glutenin and gliadins, which are rich in proline ...
Cell-free DNA (cfDNA) has emerged as a promising biomarker for non-invasive cancer diagnostics, offering a window into tumor-derived genetic and epigenetic information through simple blood sampling. However, the biological ...
This thesis explores the development and evaluation of a smart, multi-agent system designed to retrieve information efficiently from a diverse biomedical knowledge graph. The graph was carefully built using BioKG data in ...
Enhancers and their non-coding counterparts, enhancer RNAs (eRNAs), are crucial regulators of gene expression, directing cellular identity, developmental programs, and disease states. The functional implications of enhancer ...
Calendula officinalis (marigold) has long been valued in traditional medicine for its therapeutic effects, yet the molecular mechanisms underlying its action remain largely unexplored. This study investigates the bioactive ...
Alam, Urooj; Raghava, Gajendra Pal Singh (Advisor)(IIIT-Delhi, 2025-05)
The inherent instability of peptides in biological fluids represents a significant challenge for their development as therapeutic agents. To advance the field, we have developed a database of peptide half-life called ...
Tomer, Ritu; Raghava, Gajendra Pal Singh (Advisor)(IIIT-Delhi, 2025-10)
Developments in computational biology have facilitated the systematic study of biomolecules including peptides, proteins or nucleic acids. Such advancements have provided disease-oriented research and therapeutic discovery ...
Cholesteryl Ester Transfer Protein (CETP) exchanges cholesteryl esters (CEs) and triglycerides (TGs) between lipoproteins, modulating their composition. This process regulates plasma CE and TG content and therefore strongly ...
Akanksha; Raghava, Gajendra Pal Singh (Advisor)(IIIT-Delhi, 2025-09)
Non-invasive diagnostics and therapeutics have the potential to revolutionize clinical practices by providing patient-friendly, accessible, and pain-free alternatives to traditional invasive methods. Among various biofluids, ...
G-protein-coupled receptors (GPCRs) are vital pharmaceutical targets, with more than one-third of FDA-approved drugs influencing their function. While central to cellular signaling and drug development, GPCR research is ...
CRISPR/Cas, a recently discovered genome-editing method depends on a single protein (Cas9) and non-coding RNA for gene-editing, which makes it simple, more rapid, versatile, efficient and manipulatable. Despite the ...
Understanding and predicting complex biological processes, from the interactions of molecules to the aging of cells, relies heavily on the ability to extract useful information from different types of biological data. ...
Cellular metabolites, traditionally seen as intermediates in metabolic pathways, perform diverse roles that extend into cellular signaling, homeostasis, and disease progression. This study deciphers the multifaceted roles ...
Cooking is a quintessential creative pursuit with profound significance for humanity. Food and cooking transcend mere sensory pleasure and have serious nutrition and public health outcomes. Beyond being linked to the ...
It is rare for individual genes to exert influence on biological processes in isolation. Instead, they are controlled by intricate networks of genes that collaborate in a well-organized manner. Complex biological processes ...
R Chandra, Omkar; Kumar, Vibhor (Advisor)(IIIT-Delhi, 2024-07-01)
There are thousands of genes with incomplete functional annotations, particularly non-coding genes. Understanding the functional roles of genes is crucial for dissecting the complex genomic regulatory mechanisms underlying ...
The escalating volume and intricate nature of healthcare and social care datasets necessitate the implementation of unconventional feature learning strategies to tackle current challenges. The examination of health and ...
Oral health is essential for overall human well-being, with oral diseases impacting 3.5 billion people worldwide every year (WHO Report 2022). Oral microbiome is considered as the 2nd most abundant human body site with ...