Data-driven exploration of cross-body site interactions between oral and gut microbiome

Abstract

This study investigates the link between the oral and gut microbiome, two highly diverse microbial communities with established connections to human health. We per formed meta-analysis on across those studies containing cross-body-site sample for oral and gut. We analyzed those paired oral-gut microbiome data from over 1600 in- dividuals across 12 global cohorts. Our findings reveal a strong correlation between the composition of these microbiomes. Interestingly, we identified distinct groups of oral bacteria that appear to selectively influence either beneficial or detrimental members of the gut microbiota. In this study, we present the results and investigate the inter-relatedness, transmission pattern, connecting links and reproducibly predicting microbes. We identified extent of oral microbial species in the gut environment. These findings can potentially help to advance the understanding of interaction patterns be- tween cross-body sites. This study suggests the potential for the oral microbiome to be utilized as part of targeted interventions aimed at reducing the risk and progression of gut-related diseases.